NEVARI

Reference Dossier

Active Ingredients

Natural bioengineered actives, dosed at clinical concentration. Every compound below appears in one or more Nevari formulations with full INCI, CAS registry number, and molecular formula.

Hyaluronic Acid

Humectant / Hydrator
INCI
Sodium Hyaluronate
CAS
9067-32-7
Formula
(C₁₄H₂₀NNaO₁₁)ₙ

Multi-molecular-weight hydration. Surface plumping at high MW; intradermal hydration at low MW. Improves elasticity and visible smoothness.

Used in: Serums, Toners, Eye Creams, Moisturisers

Polyglutamic Acid

Superhumectant
INCI
Polyglutamic Acid
CAS
25513-46-6
Formula
(C₅H₇NO₃)ₙ

Binds 4× the moisture of hyaluronic acid. Forms a breathable film that slows transepidermal water loss.

Used in: Serums, Moisturisers

Glycerin

Humectant
INCI
Glycerin
CAS
56-81-5
Formula
C₃H₈O₃

Universal hydrator. Draws atmospheric and dermal moisture into the stratum corneum, improving softness and barrier flexibility.

Used in: Cleansers, Toners, Lotions, Body Washes

D-Panthenol

Humectant / Pro-Vitamin
INCI
D-Panthenol
CAS
81-13-0
Formula
C₉H₁₉NO₄

Provitamin alcohol that converts to pantothenic acid in skin. Improves softness, accelerates barrier repair.

Used in: Toners, Moisturisers, Shampoos

Urea

Keratolytic / Humectant
INCI
Urea
CAS
57-13-6
Formula
CH₄N₂O

Endogenous component of natural moisturising factor. Hydrates at low concentration; softens hyperkeratosis at higher dose.

Used in: Moisturisers, Hand Creams, Body Lotions

Sodium PCA

Natural Moisturizing Factor
INCI
Sodium PCA
CAS
28874-51-3
Formula
C₅H₆NNaO₃

Sodium salt of pyrrolidone carboxylic acid — a primary component of the skin's intrinsic NMF system. Enhances moisture retention at the corneocyte level.

Used in: Toners, Serums

Niacinamide

Antioxidant / Barrier Support
INCI
Niacinamide
CAS
98-92-0
Formula
C₆H₆N₂O

Amide form of nicotinic acid. Refines pore appearance, evens tone, strengthens the lipid barrier, regulates sebum.

Used in: Toners, Serums, Body Serums, Moisturisers

Ascorbyl Phosphate

Antioxidant / Brightener
INCI
Sodium Ascorbyl Phosphate
CAS
66170-10-3
Formula
C₆H₆Na₃O₉P

Stable, water-soluble ascorbic acid precursor. Brightens hyperpigmentation, supports collagen synthesis, neutralises free radicals.

Used in: Serums, Body Serums

L-Ascorbic Acid

Antioxidant / Brightener
INCI
Ascorbic Acid
CAS
50-81-7
Formula
C₆H₈O₆

Pure vitamin C. Highest-potency antioxidant in topical use; cofactor in collagen biosynthesis; inhibits tyrosinase to fade discolouration.

Used in: High-Potency Serums, Boosters

Tocopherol

Antioxidant / Lipid Stabiliser
INCI
Tocopherol
CAS
59-02-9
Formula
C₂₉H₅₀O₂

Lipid-soluble antioxidant. Quenches peroxyl radicals, stabilises lipid phases in formulation, supports cutaneous healing.

Used in: Serums, Oils, Sunscreens, Lip Care

Ferulic Acid

Antioxidant Synergist
INCI
Ferulic Acid
CAS
1135-24-6
Formula
C₁₀H₁₀O₄

Hydroxycinnamic acid. Stabilises ascorbic acid and tocopherol, doubling their photoprotective performance.

Used in: Antioxidant Serums

Resveratrol

Antioxidant / Longevity
INCI
Resveratrol
CAS
501-36-0
Formula
C₁₄H₁₂O₃

Stilbene polyphenol. Activates sirtuin pathways linked to cellular longevity; neutralises ROS overnight.

Used in: Night Serums, Eye Creams

Epigallocatechin Gallate

Polyphenol Complex
INCI
Epigallocatechin Gallate
CAS
989-51-5
Formula
C₂₂H₁₈O₁₁

Dominant catechin polyphenol. Inhibits MMP-1 collagen-degrading enzymes, modulates UV-induced inflammation.

Used in: Serums, Toners

Carnosic Acid

Polyphenol Complex / Scalp Active
INCI
Carnosic Acid
CAS
3650-09-7
Formula
C₂₀H₂₈O₄

Phenolic diterpene. Activates follicular microcirculation, scavenges scalp free radicals, supports hair-growth signalling.

Used in: Shampoos, Conditioners

Ginkgolide B

Polyphenol Complex / Microcirculatory
INCI
Ginkgolide B
CAS
15291-77-7
Formula
C₂₀H₂₄O₁₀

Terpene lactone. Improves capillary flow at the dermal-epidermal junction; supports under-eye drainage and tonic recovery.

Used in: Eye Creams, Concentrates

Retinol

Retinoid / Cell Turnover
INCI
Retinol
CAS
68-26-8
Formula
C₂₀H₃₀O

Vitamin A alcohol. Converts to retinoic acid in skin; accelerates corneocyte turnover, stimulates fibroblasts, refines texture.

Used in: Night Serums, Eye Creams

Bakuchiol

Biomimetic Retinoid / Meroterpene Complex
INCI
Bakuchiol
CAS
10309-37-2
Formula
C₁₈H₂₄O

Meroterpene functioning as a retinoid biomimetic. Upregulates collagen Types I, III, IV via the same gene pathway as retinoic acid — without retinoid irritation.

Used in: Night Serums

Salicylic Acid

BHA Exfoliant
INCI
Salicylic Acid
CAS
69-72-7
Formula
C₇H₆O₃

Lipophilic beta-hydroxy acid. Penetrates sebum to dissolve intrapore debris; anti-inflammatory at low concentration.

Used in: Cleansers, Peels

Glycolic Acid

AHA Exfoliant
INCI
Glycolic Acid
CAS
79-14-1
Formula
C₂H₄O₃

Smallest alpha-hydroxy acid. Loosens corneodesmosomes for rapid surface exfoliation, brightening, and improved penetration of follow-on actives.

Used in: Cleansers, Boosters, Peels

Lactic Acid

AHA Exfoliant (Gentle)
INCI
Lactic Acid
CAS
50-21-5
Formula
C₃H₆O₃

Larger-molecule AHA. Slower penetration than glycolic acid; doubles as a humectant via NMF compatibility.

Used in: Peels, Boosters

Mandelic Acid

AHA Exfoliant (Pigment-Safe)
INCI
Mandelic Acid
CAS
90-64-2
Formula
C₈H₈O₃

Large-molecule AHA with the slowest penetration profile. Brightens without inflammatory PIH risk; ideal for melanin-rich skin.

Used in: Peels, Brightening Serums

Gluconolactone

PHA Exfoliant
INCI
Gluconolactone
CAS
90-80-2
Formula
C₆H₁₀O₆

Polyhydroxy acid. Larger molecular structure means surface-level resurfacing with no compromise to barrier integrity. Suitable for daily use on sensitive skin.

Used in: Toners, Gentle Peels

Azelaic Acid

Anti-Inflammatory / Brightener
INCI
Azelaic Acid
CAS
123-99-9
Formula
C₉H₁₆O₄

Dicarboxylic acid. Inhibits tyrosinase to fade post-inflammatory hyperpigmentation, normalises follicular keratinisation, anti-inflammatory.

Used in: Boosters, Spot Treatments

Acetyl Hexapeptide-8

Signal Peptide / Expression-Line
INCI
Acetyl Hexapeptide-8
CAS
616204-22-9
Formula
C₃₄H₆₀N₈O₁₂S

SNAP-25 inhibiting peptide. Attenuates the neurotransmitter signal that drives repetitive expression contraction; visibly softens dynamic lines.

Used in: Firming Serums, Day Creams, Eye Creams

Palmitoyl Tripeptide-1

Signal Peptide / Collagen Activator
INCI
Palmitoyl Tripeptide-1
CAS
147732-56-7
Formula
C₃₀H₅₈N₆O₅

Matrikine fragment of collagen Type I. Triggers fibroblast feedback to synthesise new collagen, fibronectin and hyaluronan.

Used in: Firming Serums, Eye Creams

Palmitoyl Tetrapeptide-7

Signal Peptide / Anti-Glycation
INCI
Palmitoyl Tetrapeptide-7
CAS
221227-05-0
Formula
C₃₂H₆₂N₆O₆

Downregulates interleukin-6 to reduce glycation-driven inflammation. Often paired with Palmitoyl Tripeptide-1 in Matrikine-class systems.

Used in: Firming Serums, Eye Creams

Copper Tripeptide-1

Signal Peptide / Wound-Healing
INCI
Copper Tripeptide-1
CAS
89030-95-5
Formula
C₁₄H₂₄CuN₆O₃

Endogenous copper-binding tripeptide (GHK-Cu). Activates antioxidant defense enzymes; supports glycosaminoglycan synthesis and dermal remodelling.

Used in: Concentrates, Recovery Serums

Ceramide NP

Barrier Repair / Lipid
INCI
Ceramide NP
CAS
100403-19-8
Formula
C₃₄H₆₇NO₄

Native epidermal ceramide. Reconstitutes the intercellular lipid lamellae that constitute approximately 50% of stratum-corneum lipids.

Used in: Serums, Night Creams, Body Lotions

Phytosphingosine

Ceramide Precursor
INCI
Phytosphingosine
CAS
554-62-1
Formula
C₁₈H₃₉NO₃

Sphingoid base precursor to endogenous ceramides. Encourages the skin's own ceramide biosynthesis; antimicrobial against pore-resident bacteria.

Used in: Moisturisers, Eye Creams

Squalane

Emollient / Barrier Lipid
INCI
Squalane
CAS
111-01-3
Formula
C₃₀H₆₂

Saturated, oxidatively stable analogue of skin's intrinsic squalene. Reinforces the barrier with a non-comedogenic, weightless lipid film.

Used in: Serums, Oils, Lotions, Conditioners

C20–C22 Wax Ester Complex

Wax Ester / Sebum-Mimetic
INCI
Simmondsia Chinensis Seed Oil
CAS
61789-91-1
Formula
C₄₂H₈₂O₂

Long-chain wax ester profile that closely matches human sebum composition. Balances sebum output without comedogenicity.

Used in: Facial Oils, Conditioners, Night Creams

C16–C18 Triglyceride Complex

Lipid Complex / Occlusive
INCI
Butyrospermum Parkii Butter
CAS
194043-92-0
Formula
Triglyceride blend

Stearic / oleic triglyceride matrix. Forms a flexible occlusive layer for intense moisture retention and cold-weather protection.

Used in: Body Lotions, Hand Creams, Lip Care

Tocopherol-Carotenoid Lipid Complex

Lipid Complex / Regenerative
INCI
Rosa Canina Fruit Oil
CAS
84603-93-0
Formula
Fatty-acid / tocopherol blend

Linoleic / linolenic acid matrix with bound tocopherols and trans-retinoic-acid precursors. Improves discolouration and texture irregularity over time.

Used in: Facial Oils, Night Serums

Tranexamic Acid

Brightener / Pigment Pathway
INCI
Tranexamic Acid
CAS
1197-18-8
Formula
C₈H₁₅NO₂

Lysine analogue. Interrupts the plasmin–prostaglandin axis that drives UV-triggered melanogenesis. Addresses melasma and persistent hyperpigmentation.

Used in: Brightening Serums

Asiaticoside

Triterpene Complex / Soothing
INCI
Asiaticoside
CAS
16830-15-2
Formula
C₄₈H₇₈O₁₉

Triterpene saponin. Stimulates fibroblast proliferation and collagen synthesis; calms erythema and supports barrier recovery.

Used in: Serums, Moisturisers, Cleansers

Madecassoside

Triterpene Complex / Anti-Inflammatory
INCI
Madecassoside
CAS
34540-22-2
Formula
C₄₈H₇₈O₂₀

Pentacyclic triterpene. Suppresses TNF-α and other pro-inflammatory cytokines; accelerates re-epithelialisation post-resurfacing.

Used in: Recovery Serums, Post-Procedure Care

Cannabidiol

Phytocannabinoid / Anti-Inflammatory
INCI
Cannabidiol
CAS
13956-29-1
Formula
C₂₁H₃₀O₂

Non-psychoactive cannabinoid. Modulates the cutaneous endocannabinoid system; reduces neurogenic inflammation, sebum dysregulation, and reactive flushing.

Used in: Cannabinoid Complex Booster, Recovery Serums

Bisabolol

Anti-Inflammatory / Sesquiterpene
INCI
Bisabolol
CAS
515-69-5
Formula
C₁₅H₂₆O

Monocyclic sesquiterpene alcohol. Inhibits leukotriene biosynthesis; reduces UV-induced erythema and skin reactivity.

Used in: Sensitive Skin Serums, Moisturisers

Acemannan

Mucopolysaccharide / Soothing
INCI
Aloe Barbadensis Leaf Juice
CAS
85507-69-3
Formula
(C₆H₁₁O₅)ₙ acetylated

Acetylated mannose polysaccharide. Forms a hydrophilic protective film, soothes thermal stress, supports immune-cell migration during recovery.

Used in: Cleansers, Body Washes, Sunscreens

Beta-Glucan

Immunomodulator / Soothing
INCI
Beta-Glucan
CAS
9041-22-9
Formula
(C₆H₁₀O₅)ₙ

Polysaccharide chain. Activates Langerhans cells, supports cutaneous immunity, accelerates barrier recovery post-aggression.

Used in: Recovery Serums, Sensitive-Skin Moisturisers

Allantoin

Skin Protectant / Soothing
INCI
Allantoin
CAS
97-59-6
Formula
C₄H₆N₄O₃

Uric-acid derivative. Promotes cellular proliferation and gentle keratolysis; soothes mechanical or chemical irritation.

Used in: Serums, Hand Creams, Boosters

Terpinen-4-ol

Antimicrobial Monoterpenoid
INCI
Melaleuca Alternifolia Leaf Oil
CAS
562-74-3
Formula
C₁₀H₁₈O

Cyclic monoterpenoid alcohol. Antimicrobial against C. acnes and follicular yeast; refines blemish-prone skin without stripping the barrier.

Used in: Spot Treatments, Clarifying Cleansers

Zinc PCA

Sebum Regulator
INCI
Zinc PCA
CAS
15454-75-8
Formula
C₁₀H₁₂N₂O₆Zn

Zinc salt of pyrrolidone carboxylic acid. Modulates 5α-reductase activity to normalise sebum output; antimicrobial.

Used in: Toners, Serums

Caffeine

Vasoconstrictor / Stimulant
INCI
Caffeine
CAS
58-08-2
Formula
C₈H₁₀N₄O₂

Methylxanthine alkaloid. Vasoconstricts dilated periorbital capillaries; reduces puffiness and the appearance of dark circles.

Used in: Eye Creams, Concentrates

Hydrolyzed Collagen

Structural Protein
INCI
Hydrolyzed Collagen
CAS
9007-34-5
Formula
(C₅H₉NO₂)ₙ

Enzymatically fragmented collagen peptides. Surface humectant and film-former; signals support for fibroblast collagen synthesis.

Used in: Serums, Moisturisers

Hydrolyzed Keratin

Hair Structural Protein
INCI
Hydrolyzed Keratin
CAS
69430-36-0
Formula
Variable protein

Cysteine-rich protein fragments. Diffuse into damaged cortex sites to restore tensile strength; smooth the cuticle.

Used in: Shampoos, Conditioners

Alpha-Glucan Oligosaccharide

Microbiome Support
INCI
Alpha-Glucan Oligosaccharide
CAS
9051-97-2
Formula
(C₆H₁₀O₅)ₙ

Prebiotic oligosaccharide. Selectively feeds beneficial commensals (S. epidermidis); rebalances dysbiotic skin flora.

Used in: Cleansers, Serums, Moisturisers

Ectoin

Extremolyte / Stress Shield
INCI
Ectoin
CAS
96702-03-3
Formula
C₆H₁₀N₂O₂

Cyclic amino-acid derivative biosynthesised by halophilic bacteria. Forms a hydration shell around cellular proteins; defends against UV, pollution, and osmotic stress.

Used in: Sunscreens, Sensitive Skin Products

Betaine

Osmolyte / Hydrator
INCI
Betaine
CAS
107-43-7
Formula
C₅H₁₁NO₂

Zwitterionic osmoprotectant. Equalises cellular osmotic pressure post-cleansing; restores comfort to compromised skin.

Used in: Toners, Cleansers